Ar) with a diverse range of nucleophiles to afford various trityl derivatives. This method exhibits several notable advantages: (1) wide substrate scope, compatible with N-, S-, P-, and C-centered nucleophiles, including water-sensitive organozinc reagents; (2) high regioselectivity for monofunctionalization of a single aryl ring, avoiding statistical reaction mixtures; (3) iterative ORPC reaction which enables the synthesis of both symmetric trityls with three identical substituents and asymmetric trityls with three distinct substituents; (4) significantly improved yields which are 1.5-2 fold higher than those reported in the literature. This straightforward approach provides a powerful tool for tailoring trityl radicals to advance their applications in the fields of EPR and DNP.
Xu et al. (Wed,) studied this question.