Abstract Purpose To assess the features of the 100 most-cited articles on adjunctive therapy strategies for Medication-Related Osteonecrosis of the Jaw (MRONJ). Methods The 100 most-cited articles related to adjunctive therapies for MRONJ were collected from the Web of Science. The following information was extracted from the papers: authorship, title of the paper, number of citations, the publication’s year and country, study design, journal title and impact factor, and adjunctive therapy strategies. Temporal distribution of the identified therapies was also analyzed. Results The 100 articles received a total of 6,095 citations over an 18-year period, with a notable concentration of publications from Italy. Most were descriptive observational studies, published in 55 different journals with impact factors ranging from 0.3 to 41.9. A total of 24 distinct adjunctive therapies were identified. Light-based therapies were the most prominent category ( n = 35/28.9%), encompassing photobiomodulation, laser ablation, and antimicrobial photodynamic therapy. Notably, photobiomodulation showed consistent representation throughout the entire study period, reflecting sustained interest in this modality. Conclusion The wide range of adjunctive therapies underscores the complexity of MRONJ management. Light-based therapies were the most prominent category identified, highlighting the relevance of laser-based approaches in MRONJ management. However, higher-quality evidence is required, particularly well-designed randomized clinical trials, to clarify the clinical applicability of adjunctive therapies in MRONJ.
Calderipe et al. (Thu,) studied this question.