Hydrophilic, biocompatible ligand-grafted nanodiamonds demonstrated potential to serve as a new class of nonmetallic T1 and/or T2 magnetic resonance imaging contrast agents.
Do hydrophilic polymer-grafted nanodiamonds function effectively as nonmetallic T1 and/or T2 MRI contrast agents?
Hydrophilic polymer-grafted nanodiamonds show potential as a novel class of nonmetallic T1 and/or T2 MRI contrast agents.
Nanodiamonds (NDs) have gained increasing attention in biomedical applications and theranostics owing to their exceptional physicochemical stability, biocompatibility, nontoxicity, intrinsic optical and magnetic properties, and highly adaptable surface functionalization capabilities. This study aims to generate weak surface ferromagnetism in NDs by thermally oxidizing them in air at 550 °C. Following oxidation, the NDs were grafted with hydrophilic, biocompatible ligands including dextrose, polyethylene glycol diacid, polyethylene imine, and poly(acrylic acid) to enhance their colloidal stability and biocompatibility. Through a comprehensive analysis of water proton spin relaxivities and in vivo T1 and/or T2 magnetic resonance (MR) images acquired at 3 T, this study demonstrated the potential of hydrophilic, biocompatible ligand-grafted NDs to serve as a new class of nonmetallic T1 and/or T2 MR imaging contrast agents.
Tegafaw et al. (Thu,) conducted a other in Magnetic Resonance Imaging Contrast Agents. Hydrophilic polymer-grafted nanodiamonds was evaluated on Water proton spin relaxivities and in vivo T1 and/or T2 MR images at 3 T. Hydrophilic, biocompatible ligand-grafted nanodiamonds demonstrated potential to serve as a new class of nonmetallic T1 and/or T2 magnetic resonance imaging contrast agents.