Carbamazepine (CBZ) is a widely used anticonvulsant drug that is frequently detected as an emerging pollutant with ecological and health impacts. In his work, an electrochemical microsensor based on a cavity microelectrode modified with functionalized carbon black nanoparticles ((f‐CBNPs)µCE) was developed for the sensitive and selective detection of CBZ in aqueous solution. The morphology of the modified nanomaterial was characterized by SEM, revealing a nanostructured surface with small spherical particles (size at around 100 nm) and form an interconnected conductive network, providing abundant active sites and facilitates electron and ion transport. Electrochemical characterization using cyclic voltammetry (CV) showed (i) from the study of the reversible Fe(CN) 6 3–/4– system a specific active surface area twice as large for the functionalized materials f‐CBNPs and (ii) a significant enhancement in peak current of CBZ oxidation ( factor ×11) compared with the unmodified CBNPs, corresponding to a larger specific active surface area but especially to the surface modification allowing CBZ adsorption. In order to gain in sensibility, the CV determination was applied after an electrochemical preconcentration (ECP) step on the (f‐CBNPs)µCE for 1080s at 0 V/ECS. Electrochemical impedance spectroscopy (EIS) results further demonstrated a marked decrease in charge transfer resistance indicating an impact of carbon black functionalization on charge transfer kinetics. Under optimized conditions, the sensor exhibited in ECP‐SWV a wide linear response range from 10 nM to 1.0 µM and a low detection limit of 7.4 nmol.L −1 (1.75 µg.L −1 ). The proposed method was successfully applied to the determination of carbamazepine in water and urine samples, demonstrating good recovery rates and a relative standard deviation less than 4%. The presented micro‐sensor exhibited high sensitivity and selectivity against common interfering substances, making it a promising tool for environmental monitoring and clinical applications.
Taouri et al. (Fri,) studied this question.