Adipokines such as chemerin, resistin, leptin, and apelin contribute to OSCC tumor progression, whereas zinc alpha-2-glycoprotein and adiponectin exhibit antitumourigenic effects.
What are the types of adipokines associated with Oral Squamous Cell Carcinoma (OSCC) pathogenesis and prognosis?
Adipokines play diverse, stage-specific roles in OSCC biology and may serve as potential biomarkers of disease progression, though further validation is required.
Abstract Objectives To identify and summarize the types of adipokines associated with Oral Squamous Cell Carcinoma (OSCC) pathogenesis and prognosis. Materials and Methods A comprehensive literature search was done involving Scopus, PubMed, and Embase. Studies involving adipokines in OSCC conducted in humans were included. Results Adipokines have diverse and stage-dependent effects on OSCC, including regulation of inflammation, angiogenesis, hypoxia, and tumour progression. Adipokines such as chemerin, resistin, leptin, and apelin contribute to tumour progression. Zinc alpha-2-glycoprotein and adiponectin were found to be antitumourigenic in OSCC. Methodological heterogeneity and a lack of standardized outcome measures limit comparability across studies to establish the definitive role of adipokines in OSCC. Conclusion Adipokines shape OSCC biology through diverse, stage-specific mechanisms, making them potential biomarkers of disease progression. The adipokines reported in OSCC require validation through long-term prospective studies and addressing methodological heterogeneity to serve as prognostic markers.
Velusamy et al. (Thu,) conducted a review in Oral Squamous Cell Carcinoma (OSCC). Adipokines was evaluated on OSCC pathogenesis and prognosis. Adipokines such as chemerin, resistin, leptin, and apelin contribute to OSCC tumor progression, whereas zinc alpha-2-glycoprotein and adiponectin exhibit antitumourigenic effects.