Coupling Isotope-Coded Derivatization with Fragment-Imprinted Selective Recognition for Comprehensive Analysis of Temporal Dynamics in the Serum Neurotransmitters’ Metabolic Network by UHPLC-MS/MS | Synapse
May 16, 2026
Coupling Isotope-Coded Derivatization with Fragment-Imprinted Selective Recognition for Comprehensive Analysis of Temporal Dynamics in the Serum Neurotransmitters’ Metabolic Network by UHPLC-MS/MS
Key Points
The aim is to analyze the serum neurotransmitter metabolic network using advanced profiling techniques.
Utilized isotope-coded derivatization and fragment-imprinted molecularly imprinted polymers (MMIPs).
Profiled neurotransmitter dynamics using ultrahigh-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS).
Successfully profiled neurotransmitter metabolic networks in complex biological matrices.
Demonstrated the potential for submetabolome analysis, indicating improved analytical capabilities.
Abstract
DnsCl ICD strategy with fragment-imprinted MMIPs to profile the serum NT metabolic network, demonstrating promising application prospects for submetabolome analysis in complex biological matrices.