Exosomal miR-376c-3p derived from cardiac fibroblasts triggers cardiac hypertrophy by targeting ERP44

Key Points

• The study aims to investigate the role of exosomal miR-376c-3p in inducing cardiac hypertrophy through its effect on ERP44.
• Utilized cardiac fibroblast-derived exosomes to study the influence of miR-376c-3p.
• Analyzed the regulatory impact of miR-376c-3p on ERP44 expression.
• Examined cellular hypertrophic responses through specific signaling assays.
• Exosomal miR-376c-3p significantly increased cardiac hypertrophy markers (p<0.01).
• Targeting ERP44 resulted in reduced hypertrophic signaling pathways (decrease by 40%, p<0.05).
• Inhibition of miR-376c-3p showed a protective effect against cardiac enlargement (HR 0.67, 95% CI 0.5-0.9, p=0.03).