Non-selective beta-blockers were significantly more effective than selective beta-blockers in decreasing the cumulative burden of major arrhythmic events in childhood-diagnosed LQTS (p=0.011).
Cohort (n=179)
Do non-selective beta-blockers reduce the cumulative burden of major arrhythmic events compared to selective beta-blockers in patients diagnosed with long QT syndrome during childhood?
In patients diagnosed with long QT syndrome during childhood, non-selective beta-blockers are significantly more effective than selective beta-blockers in reducing the cumulative burden of major arrhythmic events.
p-value: p=0.011
Background and aims: Congenital long QT syndrome (LQTS) is associated with the risk of major arrhythmic events (MAEs), which can be modified by beta-blocker (BB) administration. We aimed to evaluate the effects of selective vs. non-selective BBs on the cumulative burden of MAEs by performing a retrospective analysis of a cohort of LQTS patients diagnosed during childhood. Methods: = 179, female 54.7%) without structural heart disease diagnosed with LQTS (Schwartz score ≥3.5 points and/or presence of a pathogenic or likely pathogenic genetic variant) between 1985 and 2022, with a median presentation age of 10.8 and a median follow-up of 8.5 years, were included. Data were obtained from medical records, structured patient phone calls, and the National Death Registry. Results: = 0.011). Conclusions: The 20-year survival probability of patients with LQTS diagnosed during childhood was 90.2% in the BB treatment era. Non-selective BBs were significantly more effective in decreasing the cumulative MAE burden.
Tavačová 외(월) 는 선천성 길게 QT 증후군(LQTS)에서 코호트를 수행했습니다(n=179). 비선택적 베타 차단제와 선택적 베타 차단제를 비교하여 주요 부정맥 이벤트(MAE)의 누적 부담을 평가했습니다(p=0.011). 비선택적 베타 차단제가 어린 시절 진단된 LQTS에서 주요 부정맥 이벤트의 누적 부담을 감소시키는 데 있어 선택적 베타 차단제보다 유의미하게 더 효과적이었습니다(p=0.011).