Does MR tagging with CSPAMM and CAPTOR detect regional systolic and diastolic dysfunction in patients with familial hypertrophic cardiomyopathy compared to normal volunteers?
MR tagging with CSPAMM and CAPTOR can quantify regional myocardial function throughout the cardiac cycle, revealing specific regional systolic and diastolic impairments in familial hypertrophic cardiomyopathy.
Diastolic and systolic left ventricular (LV) dysfunction often significantly contribute to disabling symptoms in familial hypertrophic cardiomyopathy (FHC). This study compares regional LV function (midwall circumferential strain) during systole and diastole in eight FHC patients and six normal volunteers (NVs) using MR tagging. A prospectively-gated fast gradient-echo sequence with an echo-train readout was modified to support complementary spatial modulation of magnetization (CSPAMM) tagging and full cardiac cycle data acquisition using the cardiac phase to order reconstruction (CAPTOR), thus providing tag persistence and data acquisition during the entire cardiac cycle. Total systolic strains in FHC patients were significantly reduced in septal and inferior regions (both P < 0.01). Early-diastolic strain rates were reduced in all regions of the FHC group (all P < 0.03). The combination of CSPAMM and CAPTOR allows regional indices of myocardial function to be quantified throughout the cardiac cycle. This technique reveals regional differences in systolic and diastolic impairment in FHC patients.
Ennis et al. (Wed,) studied this question.
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