Baseline plasma renin activity, but not the ACE gene I/D polymorphism, predicted the short-term blood pressure response to 50 mg captopril in patients with essential hypertension (r = 0.497).
Observational (n=82)
Does ACE gene I/D polymorphism predict the acute blood pressure and PRA response to captopril in patients with untreated essential hypertension?
Baseline plasma renin activity, rather than ACE gene I/D polymorphism, is a useful predictor of the short-term antihypertensive response to captopril in essential hypertension.
Effect estimate: r = 0.497
Insertion/deletion (I/D) polymorphism of the angiotensin converting enzyme (ACE) gene has been shown to be a determinant for serum ACE level and a marker for several cardiovascular diseases. We investigated whether the ACE gene can predict the therapeutic efficacy of ACE inhibitors in essential hypertensive patients. The response of blood pressure and plasma renin activity (PRA) 1 h after 50 mg captopril administration were evaluated in 82 inpatients with untreated essential hypertension (42 men, 40 women; mean age +/- SD: 52 +/- 13 years; range: 27 to 79 years) in relation to ACE genotypes. There were no differences in age, gender, blood pressure, and PRA in the basal conditions, among essential hypertensive patients with the II, ID, and DD genotypes (n = 36, 34, and 12, respectively). The acute responses of PRA and blood pressure to an ACE inhibitor were similar in the three groups. The blood pressure response was negatively correlated with baseline PRA (r = 0.497). These data suggest that PRA but not the I/D polymorphism of the ACE gene is a useful predictor of the short-term antihypertensive effects of ACE inhibitors.
Yukiko Nakano (Mon,) conducted a observational in untreated essential hypertension (n=82). Captopril vs. ACE genotypes (II, ID, DD) was evaluated on Response of blood pressure and plasma renin activity (PRA) 1 h after captopril administration (r = 0.497). Baseline plasma renin activity, but not the ACE gene I/D polymorphism, predicted the short-term blood pressure response to 50 mg captopril in patients with essential hypertension (r = 0.497).
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