Epicardial endothelial dysfunction in early coronary artery disease was associated with higher lipid core plaque burden compared to normal endothelial function (9.5% vs 3.1%; P=0.042).
Cross-Sectional (n=32)
Is coronary endothelial dysfunction associated with increased intravascular lipid core plaque in patients with early coronary artery disease?
In patients with early coronary artery disease, epicardial endothelial dysfunction is associated with a higher lipid content in the vascular wall, supporting its role in early atherosclerosis pathogenesis.
Absolute Event Rate: 9.5% vs 3.1%
p-value: p=0.042
AIMS: Endothelial dysfunction is considered to play a key role in the development of atherosclerosis. However, only a limited number of human imaging studies have been available to demonstrate this hypothesis. The present study used near-infrared spectroscopy (NIRS) to investigate whether coronary endothelial dysfunction is associated with the lipid core plaque (LCP) in patients with early coronary artery disease. METHODS AND RESULTS: A total of 32 patients with chest pain who had diameter stenosis 0.98, tan: 0.84 ≤ P ≤ 0.98, orange: 0.57 ≤ P ≤ 0.84, red: P < 0.57) were measured. The mean percentage of yellow, tan, and orange colour blocks in patients with epicardial endothelial dysfunction was significantly higher than in those with normal epicardial endothelial function (9.5 ± 11.4 vs. 3.1 ± 6.5%, P = 0.042). There was a significant correlation between LCBI (r = -0.460, P = 0.008), LCBI/L (r = -0.453, P = 0.009), and maxLCBI4mm (r = -0.431, P = 0.014) and the degree of epicardial endothelial function. However, there was no significant correlation between LCBI (r = -0.101, P = 0.58), LCBI/L (r = -0.099, P = 0.59), and maxLCBI4mm (r = -0.063, P = 0.73) and the degree of microvascular endothelial function. CONCLUSION: Patients with early coronary artery disease and endothelial dysfunction had a higher lipid content in the vascular wall than patients with normal endothelial function. The result of the present study supports the hypothesis that endothelial dysfunction is associated with pathogenesis of early atherosclerosis.
Choi et al. (Sun,) conducted a cross-sectional in Early coronary artery disease (n=32). Epicardial endothelial dysfunction vs. Normal epicardial endothelial function was evaluated on Mean percentage of yellow, tan, and orange colour blocks (lipid core plaque probability) (p=0.042). Epicardial endothelial dysfunction in early coronary artery disease was associated with higher lipid core plaque burden compared to normal endothelial function (9.5% vs 3.1%; P=0.042).
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