Troponin T levels did not exceed the reference range in any of the 32 stroke patients despite elevated CK-MB in 34.4%, indicating that CK-MB elevations after stroke are likely noncardiac.
Observational (n=54)
Does CK-MB elevation after stroke indicate myocardial injury as measured by troponin T?
Elevated CK-MB after stroke is likely noncardiac in origin, as troponin T levels remain normal.
Absolute Event Rate: 0% vs 0%
Background and Purpose — Creatine kinase-MB (CK-MB) increases in some patients with stroke, with no clear evidence of an acute coronary syndrome. Its elevations have been suggested to represent a biological marker for stroke-related myocardial injury. Troponin T has superior sensitivity and specificity to CK-MB in revealing minor myocardial injury. Therefore, we studied troponin T levels after stroke to determine whether troponin T increases in parallel to CK-MB. Methods — We made daily measurements of CK-MB, myoglobin, total creatine kinase (total CK), and troponin T levels up to day 5 in 32 patients with large hemispheric infarction and with no history of coronary heart disease. The daily enzyme levels were compared with those of a control group of 22 patients with neurological diseases other than stroke. Results — Serum CK-MB, myoglobin, and total CK levels were elevated above the cutoff value in 11, 26, and 20 patients with stroke, respectively. These enzyme levels gradually increased within the first 3 days and declined afterward. Troponin T did not exceed the reference range in any patients. One patient had elevated myoglobin and 3 had elevated total CK in the control group. The difference between groups was significant for CK-MB, myoglobin, and total CK at various time points. Conclusions — Troponin T, a more specific biochemical marker of myocardial injury, does not increase after stroke. Normal troponin T along with elevated CK-MB signifies that CK-MB is not the biological marker for myocytolysis. CK-MB elevations in stroke patients are likely to be noncardiac in origin.
Ay et al. (Tue,) conducted a observational in Large hemispheric infarction (n=54). Large hemispheric infarction vs. Neurological diseases other than stroke was evaluated on Troponin T elevation above reference range. Troponin T levels did not exceed the reference range in any of the 32 stroke patients despite elevated CK-MB in 34.4%, indicating that CK-MB elevations after stroke are likely noncardiac.