Female sex is associated with half the mortality of men in acute renal failure and confers protection against renal ischemia-reperfusion injury in animal models.
What are the cellular and molecular mechanisms underlying sex differences in renal ischemia-reperfusion injury?
This review highlights that females are protected against renal ischemia-reperfusion injury compared to males and explores the underlying cellular and molecular mechanisms.
Renal ischemia-reperfusion (I/R) is an important etiopathological mechanism of acute renal failure (ARF). Despite improvements in the treatment of ARF, it is associated with significant morbidity and mortality. I/R injury also occurs during renal transplantation and leads to reduced allograft survival. Sex differences have been found in I/R injury in many different organs including the kidney. Women have half the mortality of men in ARF. In animal models also, females are protected against renal I/R injury. The mechanisms by which sex affects the outcome to renal I/R injury are being actively investigated. This review will examine the evidence for gender differences in renal I/R injury and discuss the probable mechanisms by which sex affects the renal response to I/R injury.
Kher et al. (Fri,) conducted a review in Renal ischemia-reperfusion injury and acute renal failure. Female sex vs. Male sex was evaluated. Female sex is associated with half the mortality of men in acute renal failure and confers protection against renal ischemia-reperfusion injury in animal models.