Consuming a highly pro-inflammatory diet was associated with increased odds of albuminuria (OR 1.44; 95% CI 1.02-2.03) compared to an anti-inflammatory diet in adolescents.
Cross-Sectional
Does a pro-inflammatory diet increase markers of cardiometabolic risk in adolescents?
Consuming a pro-inflammatory diet in adolescence is associated with increased cardiometabolic risk markers, including albuminuria, dyslipidemia, and altered blood pressure, particularly in overweight and obese individuals.
Effect estimate: OR 1.44 (95% CI 1.02-2.03)
BACKGROUND: The Children's Dietary Inflammatory Index (C-DII) has been validated to characterize the inflammatory potential of an individual child's diet. OBJECTIVE: To determine the association between C-DII and markers of cardiometabolic risk (adiposity, blood pressure BP, lipids, albuminuria, glomerular hyperfiltration) in adolescents. METHODS: Participants aged 12-18 enrolled in NHANES from 2005 to 2014 who completed a 24-hour dietary recall were included in this cross-sectional study. Regression models adjusted for age, sex, race and height examined associations of C-DII quartiles stratified by weight status. RESULTS: Among adolescents (mean age 15 years), the average C-DII score was 0.86 (SE 0.04). When comparing C-DII quartile 4 (most pro-inflammatory) to quartile 1 (most anti-inflammatory), there was a positive association with albuminuria (OR 1.44, 95% CI 1.02, 2.03). After stratifying by weight status, C-DII quartile was found to be significantly associated with albuminuria (OR 4.27, 95% CI 1.83, 9.92) and dyslipidemia (OR 1.87, 95% CI 1.15, 3.03) in adolescents who were overweight. Among adolescents with obesity, C-DII quartile was associated with higher SBP (β = 5.07, 95% CI 2.55-7.59) and lower DBP (β = -4.14, 95% CI -6.74, -1.54). CONCLUSION: Consuming a pro-inflammatory diet in adolescence was associated with alterations in albuminuria, lipid and BP measures.
Sethna et al. (Mon,) conducted a cross-sectional in Cardiometabolic risk. Pro-inflammatory diet (C-DII quartile 4) vs. Anti-inflammatory diet (C-DII quartile 1) was evaluated on Albuminuria (OR 1.44, 95% CI 1.02-2.03). Consuming a highly pro-inflammatory diet was associated with increased odds of albuminuria (OR 1.44; 95% CI 1.02-2.03) compared to an anti-inflammatory diet in adolescents.