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May 20, 2026Open Access

Influence of Age and Gender on Short-Term Efficacy, Acceptability and Safety of Antipsychotic Drug Treatment of Adolescents With Schizophrenia: An Individual Patient Data Meta-Analysis

Key Points

The study aims to assess how age and gender impact the efficacy, acceptability, and safety of antipsychotic treatments in adolescents with schizophrenia.
Individual patient data meta-analysis of antipsychotic treatment efficacy and safety.
Analysis included diverse participant demographics focusing on age and gender.
Review of prior clinical trials and studies related to antipsychotic medications.
Age significantly influences treatment efficacy, with younger adolescents showing varied responses.
Gender differences were noted in acceptability and safety profiles of antipsychotic treatments.
Overall high safety margin but highlighted the need for tailored approaches based on age and gender.

Abstract

Diversity & Inclusion Statement:We worked to ensure sex and gender balance in the recruitment of human participants.We worked to ensure race, ethnic, and/or other types of diversity in the recruitment of human participants.One or more of the authors of this paper self-identifies as a member of one or more historically underrepresented racial and/or ethnic groups in science.One or more of the authors of this paper self-identifies as a member of one or more historically

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Influence of Age and Gender on Short-Term Efficacy, Acceptability and Safety of Antipsychotic Drug Treatment of Adolescents With Schizophrenia: An Individual Patient Data Meta-Analysis

Key Points

Abstract

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