Comparative evaluation of donepezil-loaded polymeric and liposomal nanoparticles for Alzheimer's disease: biocompatibility, drug release kinetics, and cellular uptake study

Key Points

• This research aims to compare the biocompatibility and cellular uptake of donepezil-loaded nanoparticles and liposomes for Alzheimer's disease treatment.
• Evaluated the dimensions and biocompatibility of donepezil-loaded PCL/PVA nanoparticles and DPPC liposomes.
• Assessed cellular uptake of both forms of drug delivery at the nanoscale.
• Polymeric nanoparticles showed significantly greater cellular uptake than liposomal counterparts.
• Both formulations exhibited safe profiles with nanoscale dimensions.