What question did this study set out to answer?

To investigate the relationship between salivary bicarbonate and systemic acid-base balance in pediatric patients.

May 20, 2026

Salivary Bicarbonate Fails to Mirror Systemic Acid-Base Balance in Pediatric Patients at Risk of Metabolic Disturbances.

NPNicola Bertazza PartigianiUniversity of Padua MMMarco MoiUniversity of Padua ADAlessandro D'UvaUniversity of Padua

Key Points

To investigate the relationship between salivary bicarbonate and systemic acid-base balance in pediatric patients.
Evaluated salivary bicarbonate levels in pediatric patients at risk for metabolic disturbances.
Compared salivary bicarbonate levels in subjects with advanced chronic kidney disease.
Salivary bicarbonate levels did not correlate with systemic acid-base balance.
Salivary bicarbonate was elevated in patients with advanced chronic kidney disease.

Abstract

Salivary bicarbonate does not reflect systemic acid-base balance but is elevated in advanced CKD, suggesting a local regulatory phenomenon worthy of further exploration.

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