Abstract Rationale Interstitial Lung Abnormalities (ILA) are incidental findings on thoracic computer tomography imaging, which may subsequently progress to interstitial lung disease (ILD). Assessment of individuals with ILA is recommended to risk stratify and identify modifiable risk factors. The aim of the study is to report the frequency of modifiable risk factors in a well characterised ILA cohort. Method Data was collected prospectively from patients, who were reviewed in a dedicated ILA clinic in a tertiary UK ILD centre. Patients were reviewed from August 2023 to July 2025. Baseline demographics, smoking status, symptoms, occupational and exposure history and family history were collected using a standardised proforma. Avian and aspergillus immunoglobulins were recorded. Descriptive statistics were used to report the frequency of identifiable risk factors. To report the possibility of occult systemic autoimmune rheumatic disease, symptoms and autoimmune serology were compared to the American thoracic Society, Interstitial Pneumonia with Autoimmune Features (IPAF) classification. Results A total of 110 individuals were reviewed in the ILA clinic (58 male 52.7%, mean age 70.6±standard deviation 8.1). 50 individuals (45.5%) had a fibrotic ILA and 60 (54.5%) had non-fibrotic. 10 (9.1%) were current smokers and 7 (6.4%) were current vapers. 12 individuals (10.9%) reported avian exposure with one current exposure. 15 (13.6%) reported current feather bedding exposure. 27 (24.5%) had a positive avian antigen although only four of these reported avian or feather exposure. 10 (9.1%) reported mould exposure. 33 (30%) had a positive aspergillus IgG. 46 (41.8%) reported occupational vapours, gases, dusts and fumes (VGDF) exposure of which 8 reported current exposure. 21 (19.2%) reported historic asbestos exposure. 14 (12.7%) individuals reported symptoms consistent with the clinical domain of IPAF and 10 (9.1%) individuals had positive antibodies consistent with IPAF with two having both symptoms and antibodies. 6 (5.5%) individuals reported a family history of a first degree relative with pulmonary fibrosis, which was not previously disclosed before initial assessment. Conclusions We identified a significant number of modifiable risk factors in individuals with ILA, which highlights the importance of dedicated clinical ILA assessment as this allows the opportunity for positive intervention. This abstract is funded by: None
Hardy et al. (Fri,) studied this question.