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Acid-catalyzed electrophilic trifluoromethylation of nitriles in the presence of azoles leads to N-(trifluoromethyl)imine derivatives. The source of the trifluoromethyl group is a readily prepared and easy-to-handle hypervalent iodine(III) reagent (see scheme; HNTf2=bis(N-(trifluoromethanesulfonyl)imide). This Ritter-type reaction is astraightforward approach to N-(trifluoromethyl)imidoyl azoles, compounds otherwise very difficult to access. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Niedermann et al. (Thu,) studied this question.