What question did this study set out to answer?

Investigate the impact of THC use on TMS treatment effectiveness for PTSD.

May 21, 2026Open Access

Magnetic Resonance Therapy (MeRT) for PTSD in a Real-World Clinical Setting

Key Points

Investigate the impact of THC use on TMS treatment effectiveness for PTSD.
Conducted a retrospective matched analysis comparing THC users and non-users during TMS.
Evaluated response and remission rates as well as PHQ-9 score changes pre- and post-treatment.
Response rates were 56.6% for non-THC users and 50.9% for THC users (p=0.559).
Remission rates were 18.9% for non-THC users and 17.0% for THC users (p=0.800).
No significant difference was observed in PHQ-9 score change between groups (p=0.347).

Abstract

following TMS.Response rates were comparable between non-THC users (56.6%) and active users (50.9%; p=0.559), as were remission rates for non-THC users (18.9%) and active users (17.0%; p=0.800).Independent samples t-tests demonstrated no difference in pre-to post-TMS PHQ-9 change between groups (p=0.347).Discussion: In this retrospective matched analysis, concurrent THC use during TMS was not associated with differential clinical outcomes compared with non-use.These findings suggest THC use during treatment doesn't meaningfully alter TMS effectiveness.Larger prospective studies are warranted to further elucidate the relationship between cannabis use patterns and TMS clinical outcomes for MDD.

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Cite This Study

Cole et al. (Mon,) studied this question.

synapsesocial.com/papers/6a0ea074be05d6e3efb5f34d https://doi.org/https://doi.org/10.1016/j.transm.2026.100274

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