Delayed resolution of initial symptoms (≥6 days) in dialysis patients with COVID-19 was significantly associated with a ≥3.6% decrease in Geriatric Nutritional Risk Index or death at 3 months.
Cohort (n=153)
No
Does delayed resolution of initial COVID-19 symptoms predict worse outcomes in vulnerable dialysis patients?
Delayed resolution of initial COVID-19 symptoms (≥ 6 days) is a useful indicator for predicting poor prognosis, including nutritional deterioration and death, in vulnerable dialysis patients.
ABSTRACT Introduction Among vulnerable dialysis patients, initial symptom duration of coronavirus disease 2019 (COVID‐19) has not been investigated extensively. Methods We analyzed 153 dialysis patients with COVID‐19 in a long‐term care hospital between February 2022 and August 2023. We investigated the association between the delayed resolution of the initial symptoms (≥ 6 days), including fever or upper respiratory symptoms, and worse outcomes. These outcomes were defined as either a decrease in the Geriatric Nutritional Risk Index of ≥ 3.6% at 3 months after onset, or all‐cause death within 3 months. Results The duration of the initial symptoms was associated with worse outcomes. This association remained significant after adjustment for patient background, COVID‐19 severity, C‐reactive protein levels at onset, vaccination, and antiviral therapy, using multivariate analysis. Conclusion The duration of the initial symptoms may be a useful indicator for predicting the poor prognosis, including nutritional deterioration after COVID‐19, among vulnerable dialysis patients.
Hirai et al. (Tue,) conducted a cohort in COVID-19 in dialysis patients (n=153). Delayed resolution of initial symptoms (≥ 6 days) vs. Shorter symptom duration was evaluated on Decrease in the Geriatric Nutritional Risk Index of ≥ 3.6% at 3 months after onset, or all-cause death within 3 months. Delayed resolution of initial symptoms (≥6 days) in dialysis patients with COVID-19 was significantly associated with a ≥3.6% decrease in Geriatric Nutritional Risk Index or death at 3 months.