What question did this study set out to answer?

This research investigates an efficient method for synthesizing chiral allylic sulfones using a copper-catalyzed process.

May 21, 2026

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Copper-Catalyzed Remote Asymmetric Three-Component Sulfonylation Using SO 2 as the Sulfur Source to Access Chiral Allylic Sulfones

JLJiale LiHuaqiao University WYWenli YanEast China University of Science and Technology SLShuning LiuShanghai University

Key Points

This research investigates an efficient method for synthesizing chiral allylic sulfones using a copper-catalyzed process.
Utilized yne-allylic esters, sulfur dioxide, and cyclopropan-1-ols in a three-component reaction.
Conducted the reaction under mild conditions with focus on enantioselectivity and functional group compatibility.
Achieved high enantioselectivity of up to 96% ee.
Demonstrated broad functional group compatibility with good yields in the synthesis.

Abstract

A copper-catalyzed enantioselective sulfonylation of yne-allylic esters with sulfur dioxide and cyclopropan-1-ols is reported. This three-component reaction proceeds via selective ε-addition of γ-keto sulfinate to copper-allenylidene intermediates, enabling efficient synthesis of chiral allylic sulfones under mild conditions. The protocol features high enantioselectivity (up to 96% ee), broad functional group compatibility, and good yields.

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Cite This Study

Li et al. (Tue,) studied this question.

synapsesocial.com/papers/6a0ea196be05d6e3efb606d0 https://doi.org/https://doi.org/10.1021/acs.orglett.6c01600

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