Inpatient CRT implantations in the US from 2003 to 2013 had an overall complication rate of 6.1%, which significantly increased over the study period (P=0.01) as patient comorbidities worsened.
Observational (n=439,010)
Yes
What are the trends in utilization and in-hospital complications of CRT implantations in the US from 2003 to 2013?
Between 2003 and 2013 in the US, patients undergoing CRT implantation had increasingly severe comorbidities and a rising trend in periprocedural complications, with an overall complication rate of 6.1%.
p-value: p=0.01
Aims: Cardiac resynchronization therapy (CRT) device implantation has been shown to reduce morbidity and mortality in selected patients with heart failure. We sought to investigate the utilization and in-hospital complications of cardiac resynchronization therapy defibrillator (CRT-D) and pacemaker (CRT-P) implantations in the United States from 2003 to 2013. Methods and results: Patients receiving CRT-D or CRT-P were identified in the National Inpatient Sample database (NIS), using the International Classification of Diseases-Ninth Revision-Clinical Modification procedure codes. Annual implantation rates, patient demographics, co-morbidities, in-hospital complications, and length of stay were analysed. From 2003 to 2013, an estimated total of 439 010 (95% CI: 406 723-471 296) inpatient CRT implantations were performed in the U.S. The median age of patients was 72 and 71% were male. Overall, 6.1% had at least one complication. During the study period, comorbidity index and overall complication rate increased (P = 0.002 and P = 0.01, respectively). Mortality and length of stay showed no significant trend. Predictors of complications included: age 65 and older, female sex (OR: 1.19; 95% CI: 1.12-1.27), Deyo-Charlson Comorbidity Index, and elective admission (OR: 0.61; 95% CI: 0.57-0.66). Conclusion: From 2003 to 2013, the severity of comorbid conditions increased and a rising trend was observed in the rate of periprocedural complications among patients undergoing CRT in the United States. In-hospital mortality and length of stay showed no uniform trend.
Hosseini et al. (Wed,) conducted a observational in Heart failure (n=439,010). Cardiac resynchronization therapy (CRT-D and CRT-P) was evaluated on In-hospital complications (p=0.01). Inpatient CRT implantations in the US from 2003 to 2013 had an overall complication rate of 6.1%, which significantly increased over the study period (P=0.01) as patient comorbidities worsened.