What is the clinical evidence from this study?

Study design: Observational. Population: Dilated cardiomyopathy (n=31). Intervention: Standard supportive care (ACE inhibitors, digoxin, diuretics). Primary outcome: Clinical outcome (improved vs worsened/dead).

February 11, 2019Open Access

Clinical course of dilated cardiomyopathy in children

Key Result

In children with dilated cardiomyopathy, higher age at diagnosis, higher cardiothoracic ratio, and persistently low left ventricular ejection fraction were associated with poor clinical outcomes.

Study Design

Type

Observational (n=31)

Multicenter

Structured PICO

Population

31 children less than 12 years of age diagnosed with dilated cardiomyopathy (DCM) based on clinical examination and echocardiographic evidence of systolic ventricular dysfunction, mean age 3.5±4.03 years, 24 females and 7 males.

Outcome

Clinical outcome categorized as improved/cured (group I), no change in clinical status (group II), and worsened or dead (group III) based on clinical status and LVEF changes.composite

In children with dilated cardiomyopathy, older age at diagnosis, higher cardiothoracic ratio, and persistently low left ventricular ejection fraction are associated with poor clinical outcomes.

Limitations

Small absolute number of events and patients
Multivariate analysis of predictive variables could not be performed
Lack of sophisticated laboratory workup for etiological diagnosis

Abstract

Background: Dilated cardiomyopathy (DCM) in children is a serious disorder. Here authors study the risk factors for predicting prognosis of dilated cardiomyopathy in children.Methods: An observational case series study done in Institute of child health and research centre, Government Rajaji hospital, Madurai during September 2012 to August 2014. The diagnosis of DCM was based on clinical examination and echocardiographic evidence. Patients were followed up and grouped according to the outcome as improved or cured (group I), no change in clinical status (group II) and worsened or dead (group III).Results: 31 children less than 12 years of age were diagnosed as DCM. 13 children came under group I with a mean age of 2.15±2.5 and the mean cardiothoracic diameter ratio in chest X-ray was 59.8±3.3. The mean left ventricular ejection fraction at the time of admission was 38.7±3.04 and was 52.1±2.7 on last follow up. 11 children came under Group III with a mean age of 5.35±4.4 and the mean cardiothoracic diameter ratio was 65.3±2.7. The mean left ventricular ejection fraction was 35.8±3.7 at admission and 32.6±2.9 on last follow up. Only two children came under Group II and hence their comparison is negligible.Conclusions: Children with higher age at the time of diagnosis, higher cardiothoracic diameter ratio in chest X-ray and a low left ventricular ejection fraction on serial echocardiogram were associated with a poor outcome.

AI에게 질문

Bookmark

View Full Paper

Cite This Study

Sivakumar et al. (Mon,) conducted a observational in Dilated cardiomyopathy (n=31). Standard supportive care (ACE inhibitors, digoxin, diuretics) was evaluated on Clinical outcome (improved vs worsened/dead). In children with dilated cardiomyopathy, higher age at diagnosis, higher cardiothoracic ratio, and persistently low left ventricular ejection fraction were associated with poor clinical outcomes.

synapsesocial.com/papers/6a0eb83906ecbe833447bcab https://doi.org/https://doi.org/10.18203/2349-3291.ijcp20190501

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

AI에게 질문

Bookmark

View Full Paper