Suprofen (800 mg/day) resulted in significantly less mean fecal blood loss compared to aspirin (2,600 mg/day) (1.8 ml/day vs 4.2 ml/day; p<0.01).
RCT (n=20)
Double-blind
Crossover
Does suprofen reduce fecal blood loss compared to aspirin in healthy male subjects?
Suprofen causes significantly less gastrointestinal blood loss than high-dose aspirin in healthy males, with bleeding rates similar to placebo.
Absolute Event Rate: 1.8% vs 4.2%
p-value: p=<0.01
The effects of aspirin and suprofen on gastrointestinal blood loss were compared in a double-blind, crossover study of 20 healthy male subjects. Fecal blood loss was measured by 51Cr-labeled red cells. Subjects treated with aspirin (2,600 mg/day) experienced a mean fecal blood loss of 4.2 ml/day, compared with subjects treated with suprofen (800 mg/day) whose mean fecal blood loss was 1.8 ml/day. There was significantly greater (p less than 0.01) blood loss in the aspirin group than in the suprofen group. Mean fecal blood loss in the suprofen group did not differ appreciably from the fecal blood loss observed during the placebo period (0.4 ml/day).
Arnold et al. (Wed,) conducted a rct in Healthy volunteers (n=20). Suprofen vs. Aspirin (2,600 mg/day) and placebo was evaluated on Mean fecal blood loss (ml/day) (p=<0.01). Suprofen (800 mg/day) resulted in significantly less mean fecal blood loss compared to aspirin (2,600 mg/day) (1.8 ml/day vs 4.2 ml/day; p<0.01).