Small animal models of heart failure utilizing surgical, genetic, and pharmacological approaches provide crucial insights into pathogenesis and facilitate the development of new therapeutic strategies.
This review summarizes the strengths and limitations of various small animal models used to study the pathogenesis and treatment of heart failure.
Heart disease is a major cause of death worldwide with increasing prevalence, which urges the development of new therapeutic strategies. Over the last few decades, numerous small animal models have been generated to mimic various pathomechanisms contributing to heart failure (HF). Despite some limitations, these animal models have greatly advanced our understanding of the pathogenesis of the different aetiologies of HF and paved the way to understanding the underlying mechanisms and development of successful treatments. These models utilize surgical techniques, genetic modifications, and pharmacological approaches. The present review discusses the strengths and limitations of commonly used small animal HF models, which continue to provide crucial insight and facilitate the development of new treatment strategies for patients with HF.
Riehle et al. (Tue,) conducted a review in Heart failure. Small animal models was evaluated. Small animal models of heart failure utilizing surgical, genetic, and pharmacological approaches provide crucial insights into pathogenesis and facilitate the development of new therapeutic strategies.