Diabetes mellitus significantly increased the risk of cardiac rupture (HR 1.532) compared to non-diabetic patients among elderly patients presenting with first acute ST-segment elevated myocardial infarction.
Cohort (n=3,063)
No
Does diabetes mellitus increase the risk of cardiac rupture in aged patients presenting with first acute STEMI?
Diabetes mellitus is an independent risk factor for cardiac rupture in elderly patients presenting with their first STEMI, increasing the risk by approximately 50%.
Effect estimate: HR 1.532 (95% CI 1.054-2.346)
Absolute Event Rate: 3.36% vs 1.92%
p-value: p=0.030
Objective We aimed to analyze the risk of cardiac rupture (CR) in aged diabetic patients with acute ST-segment elevated myocardial infarction (STEMI) who were followed up for one month, and analyze its independent risk factors. Methods A total of 3063 aged patients with first onset STEMI admitted to Beijing Anzhen Hospital from January 2001 to December 2020 were retrospectively included. There were 2020 patients without diabetes mellitus (DM) and 1043 patients with DM. We used propensity scores matching (PSM) method to balance baseline exposure factors between patients with or without DM, and all were divided the DM group (1043 cases) and the non-DM group (1043 cases) after the PSM. The primary outcome was CR (the composite rate of papillary muscle rupture, ventricular septum perforation, free wall rupture), which was diagnosed based on clinical manifestations and/or echocardiographic findings. Kaplan-meier survival analyses and log-rank test was used to evaluate the risk of CR between the two groups, and Cox regression analysis was used to evaluate the independent risk factors for CR. Results After PSM, the baseline clinical data were similar between the DM and non-DM group (all P 0.05). However, level of glycated hemoglobin was significantly higher in the DM group ( P 0.05). During 1 month of follow-up, there were 55 (2.64%) cases of CR, most occurred within 48h after admission (40 cases). Among the 55 cases, 11(0.53%) had papillary muscle rupture, 18(0.86%) had ventricular septum perforation, and 26(1.25%) had free wall rupture. Kaplan-meier survival analyses detected that the DM group was associated with significantly increased risk of CR (3.36% vs. 1.92%, HR =1.532, 95% CI : 1.054-2.346, P =0.030), ventricular septum perforation (1.05% vs. 0.67%, HR =1.464, 95% CI : 1.021-2.099, P =0.038) and free wall rupture (1.63% vs. 0.86%, HR =1.861, 95% CI : 1.074-3.225, P =0.027) than those in the non-DM group. Among the 2031 aged STEMI patients without CR, 144 cases (6.90%, 144/2086) died; and among the 55 patients with CR, 37 cases (1.77%, 37/2086) died due to CR. Therefore, twenty percent (20.44%, 37/181) of death was due to CR. Multivariate Cox regression analysis indicated that DM ( HR =1.532, 95% CI : 1.054-2.346), age ( HR =1.390, 95% CI : 1.079-1.791), female ( HR =1.183, 95% CI : 1.049-1.334), troponin I ( HR =1.364, 95% CI : 1.108-1.679), brain natriuretic peptide ( HR =1.512, 95% CI : 1.069-2.139), revascularization ( HR =0.827, 95% CI : 0.731-0.936) and β-receptor blocker ( HR =0.849, 95% CI : 0.760-0.948) were independent risk factors of CR (all P 0.05). Conclusion DM as well as a few other factors, are independent determinants of CR. CR is not a rare event among the aged STEMI patients and twenty percent of deaths are due to CR. However, large sample-sized studies are warranted to confirm these findings.
Zu et al. (Tue,) conducted a cohort in Acute ST-segment elevated myocardial infarction (STEMI) (n=3,063). Diabetes Mellitus vs. Non-Diabetes Mellitus was evaluated on Cardiac rupture (composite of papillary muscle rupture, ventricular septum perforation, free wall rupture) (HR 1.532, 95% CI 1.054-2.346, p=0.030). Diabetes mellitus significantly increased the risk of cardiac rupture (HR 1.532) compared to non-diabetic patients among elderly patients presenting with first acute ST-segment elevated myocardial infarction.