Women had a significantly higher risk of hospital admission due to adverse drug reactions from low-ceiling diuretics compared to men (RR 4.02).
Observational (n=14,207)
Yes
Do hospital admissions for adverse drug reactions due to cardiovascular drugs differ between men and women?
Significant sex differences exist in hospital admissions for adverse drug reactions to cardiovascular drugs, with women at markedly higher risk for admissions related to diuretics and cardiotonic glycosides.
Effect estimate: RR 4.02 (95% CI 3.12-5.19)
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Cardiovascular disease, disease outcome, drug treatment and drug response differ between men and women. WHAT THIS STUDY ADDS • Adverse drug reactions attributed to cardiovascular drugs that require hospital admission show differences between men and women, even after taking into account age and the total number of drug prescriptions. AIMS Cardiovascular disease in women is often underestimated. The effects of cardiovascular drugs differ between the sexes because of pharmacokinetic and pharmacodynamic differences. Adverse drug reactions (ADRs) within these drug classes may have serious consequences, leading to hospital admission. We aimed to study differences between men and women in hospital admissions for ADRs due to cardiovascular drugs. METHODS We conducted a nationwide study of all hospital admissions between 2000 and 2005 with data from the Dutch National Medical Register. Relative risks were calculated of hospital admissions due to ADRs to the different cardiovascular drug groups for women compared with men. By an ecological design, risks were adjusted for the total number of Dutch inhabitants and the total number of prescriptions. RESULTS In total, 14 207 of the hospital admissions (34% of all ADR‐related admissions) were attributed to cardiovascular drugs 7690 in women (54%; 95% confidence interval 53–55%). ‘Anticoagulants and salicylates’ ( n = 8988), ‘high‐ and low‐ceiling diuretics’ ( n = 2242) and ‘cardiotonic glycosides’ ( n = 932) were responsible for the majority of the ADR‐related hospital admissions. The most pronounced sex differences were seen in users of low‐ceiling diuretics (relative risk 4.02; 95% confidence interval 3.12–5.19), cardiotonic glycosides (relative risk 2.38; 95% confidence interval 2.06–2.74), high‐ceiling diuretics (relative risk 2.10; 95% confidence interval 1.91–2.32) and coronary vasodilators (relative risk 0.77; 95% confidence interval 0.65–0.91). CONCLUSIONS Clear sex differences exist in ADRs requiring hospital admission for different cardiovascular drug groups. Sex differences should be taken into account in the prescription and evaluation of drugs.
Rodenburg et al. (Thu,) conducted a observational in Cardiovascular drug-induced adverse reactions (n=14,207). Female sex (cardiovascular drug users) vs. Male sex was evaluated on Hospital admission due to adverse drug reactions from low-ceiling diuretics (RR 4.02, 95% CI 3.12-5.19). Women had a significantly higher risk of hospital admission due to adverse drug reactions from low-ceiling diuretics compared to men (RR 4.02).