Right ventricular systolic dysfunction in patients with HFPEF was associated with significantly higher one-year all-cause mortality compared to normal RV function (41.7% vs 4.8%, HR 11.5, P=0.004).
Cohort (n=95)
Does right ventricular systolic dysfunction predict mortality in patients with heart failure with preserved ejection fraction?
Right ventricular systolic dysfunction is a strong independent predictor of one-year all-cause and cardiovascular mortality in patients with heart failure with preserved ejection fraction.
Effect estimate: HR 11.5 (95% CI 2.2 to 59.5)
Absolute Event Rate: 41.7% vs 4.8%
p-value: p=0.004
OBJECTIVE: The prognostic impact of right ventricular systolic dysfunction (RVSD) in heart failure (HF) with preserved ejection fraction (HFPEF) is not sufficiently understood. This pilot study evaluates the prevalence and prognostic impact of RVSD in HFPEF. METHODS: Ninety-five consecutive patients, admitted due to HF within one year were included and followed up for 12 months. Patients were classified based on left ventricular ejection fraction (LVEF) into two groups: HFPEF (LVEF >40%; n = 54), and heart failure with reduced ejection fraction (HFREF) (LVEF < or = 40%; n = 41). RVSD was defined as peak systolic tricuspid annular velocity (S') <10.8 cm/s. RESULTS: The prevalence of RVSD was 22% vs 59%, in HFPEF vs HFREF, respectively (P < 0.001). Patients with HFPEF and RVSD had significantly higher one-year all-cause mortality compared to HFPEF with normal RV function (41.7% vs. 4.8%, P = 0.004). The same trend was found in HFREF (33.3% vs. 5.9%, P = 0.057). A similar outcome was obser ved in cardiovascular mortality (H FPEF 33.3% vs. 0%, P = 0.002 and HFREF 20.8% vs. 0%, P= 0.06). RVSD was the only independent predictor of all-cause one-year mortality in patients with HFPEF (HR 11.5, 95% Cl 2.2 to 59.5, p = 0.004). CONCLUSION: RVSD is an independent predictor of all-cause mortality in HFPEF. Patients with HFPEF and RVSD had significantly higher one-year all-cause and cardiovascular mortality than those with normal RV function.
Cenkerova et al. (Sat,) conducted a cohort in Heart failure with preserved ejection fraction (HFPEF) and reduced ejection fraction (HFREF) (n=95). Right ventricular systolic dysfunction (RVSD) vs. Normal right ventricular function was evaluated on One-year all-cause mortality in HFPEF (HR 11.5, 95% CI 2.2 to 59.5, p=0.004). Right ventricular systolic dysfunction in patients with HFPEF was associated with significantly higher one-year all-cause mortality compared to normal RV function (41.7% vs 4.8%, HR 11.5, P=0.004).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: