Weight loss significantly reduced clinic systolic blood pressure by 5.79 mmHg (95% CI, 3.54-8.05), with larger reductions (8.54 mmHg) seen in patients achieving a BMI decrease ≥3 kg/m2.
Meta-Analysis (n=3,219)
Does weight loss reduce clinic and ambulatory blood pressure in patients with obesity or overweight?
Weight loss significantly reduces both clinic and ambulatory blood pressure in overweight and obese patients, with greater BMI reductions yielding larger blood pressure decreases.
Effect estimate: Mean reduction 5.79 mmHg SBP (95% CI 3.54-8.05)
Abstract To determine quantitative differences between weight loss and changes in clinic blood pressure (BP) and ambulatory BP in patients with obesity or overweight, the authors performed a meta‐analysis. PubMed, Embase, and Scopus databases were searched up to June 2022. Studies that compared clinic or ambulatory BP with weight loss were included. A random effect model was applied to pool the differences between clinic BP and ambulatory BP. Thirty‐five studies, for a total of 3219 patients were included in this meta‐analysis. The clinic systolic blood pressure (SBP) and diastolic blood pressure (DBP) were significantly reduced by 5.79 mmHg (95% CI, 3.54–8.05) and 3.36 mmHg (95% CI, 1.93–4.75) after a mean body mass index (BMI) reduction of 2.27 kg/m 2 , and the SBP and DBP were significantly reduced by 6.65 mmHg (95% CI, 5.16–8.14) and 3.63 mmHg (95% CI, 2.03–5.24) after a mean BMI reduction of 4.12 kg/m 2 . The BP reductions were much larger in patients with a BMI decrease ≥3 kg/m 2 than in patients with less BMI decrease, both for clinic SBP 8.54 mmHg (95% CI, 4.62–12.47) versus 3.83 mmHg (95% CI, 1.22–6.45) and clinic DBP 3.45 mmHg (95% CI, 1.59–5.30) versus 3.15 mmHg (95% CI, 1.21–5.10). The significant reduction of the clinic and ambulatory BP followed the weight loss, and this phenomenon could be more notable after medical intervention and a larger weight loss.
Yang et al. (Mon,) conducted a meta-analysis in obesity or overweight (n=3,219). Weight loss vs. Baseline or less weight loss was evaluated on Changes in clinic and ambulatory blood pressure (Mean reduction 5.79 mmHg SBP, 95% CI 3.54-8.05). Weight loss significantly reduced clinic systolic blood pressure by 5.79 mmHg (95% CI, 3.54-8.05), with larger reductions (8.54 mmHg) seen in patients achieving a BMI decrease ≥3 kg/m2.
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