Background: Peripheral T-cell lymphomas (PTCL) remain a challenging and oftentimes fatal group of diseases in pediatrics without definitive guidelines on the optimal treatment approach. In this single institution case series, 11 cases of PTCL in children and adolescents were examined from January 2008 to April 2025 to highlight the clinical presentation, molecular findings, treatment approach, and outcome of pediatric patients with these rare lymphomas. This group showed significant clinical variability even within the same histological subtype of PTCL. Conclusions: These findings emphasize the need for a better understanding of disease biology for this complex group of malignancies to refine treatment approaches.
Devine et al. (Wed,) studied this question.
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