Higher triglyceride-glucose (TyG) index was strongly associated with an increased risk of major adverse cardiovascular events (HR 1.736) in patients with acute coronary syndrome undergoing PCI.
Observational (n=1,694)
No
Do triglyceride-derived metabolic indices predict major adverse cardiovascular events in patients with acute coronary syndrome undergoing percutaneous coronary intervention?
Triglyceride-derived metabolic indices, particularly the TyG index, are strong predictors of major adverse cardiovascular events in patients with acute coronary syndrome undergoing PCI.
Effect estimate: HR 1.736 (95% CI 1.398-2.156)
p-value: p=<0.001
BACKGROUND: Triglyceride (TG) and its related metabolic indices, all recognized as surrogates of insulin resistance, have been demonstrated to be relevant to clinical prognosis. However, the relative value of these TG-related indices for predicting cardiovascular events among patients with acute coronary syndrome (ACS) has not been examined. METHODS: The TG, the triglyceride-glucose (TyG) index, the atherogenic index of plasma, TG to high-density lipoprotein cholesterol ratio, and the lipoprotein combine index were assessed in 1694 ACS patients undergoing percutaneous coronary intervention. The primary endpoint was major adverse cardiovascular event (MACE), which was the composite of all-cause mortality, stroke, myocardial infarction, or unplanned repeat revascularization. RESULTS: < 0.05 for all comparison). CONCLUSIONS: TG and TG-derived metabolic indices were all strongly associated with MACE among ACS patients undergoing percutaneous coronary intervention. Among all the indices, TyG index showed the best ability to predict the risk of MACE.
Shao et al. (Tue,) conducted a observational in Acute coronary syndrome (n=1,694). Triglyceride-derived metabolic indices (TyG index, AIP, TG/HDL-C, LCI) vs. Lower tertiles of metabolic indices was evaluated on Major adverse cardiovascular event (MACE), composite of all-cause mortality, non-fatal MI, non-fatal ischemic stroke, or unplanned repeat revascularization (HR 1.736, 95% CI 1.398-2.156, p=<0.001). Higher triglyceride-glucose (TyG) index was strongly associated with an increased risk of major adverse cardiovascular events (HR 1.736) in patients with acute coronary syndrome undergoing PCI.