Twelve weeks of CPAP therapy significantly improved right ventricular isovolumetric acceleration by 0.5 ms2 compared to baseline in patients with newly diagnosed obstructive sleep apnoea.
Observational (n=19)
No
Does 12 weeks of CPAP improve right ventricular function (isovolumetric acceleration) in newly diagnosed patients with obstructive sleep apnoea?
12 weeks of CPAP therapy significantly improves echocardiographic markers of right ventricular function (TAPSE and IVA) in patients with newly diagnosed obstructive sleep apnoea.
Absolute Event Rate: 3% vs 2.5%
p-value: p=0.0012
BACKGROUND: Obstructive sleep apnoea (OSA) is present in 40-80% of patients with cardiovascular morbidity and is associated with adverse effects on cardiovascular health. Continuous positive airway pressure (CPAP) maintains airway patency during sleep and is hypothesised to improve cardiac function. In the present study, we report on the impact of 12 weeks of CPAP and improvements in echocardiographic parameters of the right ventricle (RV). METHODS: Nineteen newly diagnosed patients with OSA and a respiratory disturbance index (RDI) greater than 10 were enrolled. Echocardiography was performed before treatment and with a follow-up assessment after 12 weeks of CPAP. Echocardiographic and Doppler measurements were made following the American Society for Echocardiography guidelines. The primary outcome was isovolumetric acceleration (IVA). Secondary outcomes include tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), RV % strain, TEI index and RV dimension (RVD1). RESULTS: (P = 0.0012 (95% CI -0.72, -0.20)) and significant improvement of 2.05 mm in TAPSE (p = 0.0379 (95% CI -3.98 - -0.13). There was no significant difference in FAC, RV % strain, TEI index or RVD1 with twelve weeks of CPAP therapy. CONCLUSION: The present study highlights significant improvement in TAPSE and IVA with 12 weeks of CPAP treatment and no significant improvement in FAC, RVD1 and RV % strain. These data indicate favourable characteristics on both load dependent and load independent markers of RV function with CPAP.
Murphy et al. (Tue,) conducted a observational in Obstructive sleep apnoea (n=19). Continuous positive airway pressure (CPAP) vs. Baseline (pre-intervention) was evaluated on Isovolumetric acceleration (IVA) (95% CI -0.72, -0.20, p=0.0012). Twelve weeks of CPAP therapy significantly improved right ventricular isovolumetric acceleration by 0.5 ms2 compared to baseline in patients with newly diagnosed obstructive sleep apnoea.