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Osteopetrosis was induced in lethally irradiated, normal mice of grey-lethal and microphthalmic stocks by cell infusions prepared from the spleens of osteopetrotic littermates. Failure of skeletal remodeling became evident within a few weeks after transplantation as calcified cartilage and bone accumulated excessively in the active metaphyses of the long bones. The massive lesions produced were extensively infiltrated with abnormal osteoclasts.
Donald G. Walker (Fri,) studied this question.