Why the study?
Does acute administration of DPI 201-106 provoke long QT syndrome and ventricular tachyarrhythmias?
Population
Patients receiving acute administration of DPI 201-106
Design
Case_series
Follow-up
Acute
Key result
Acute administration of DPI 201-106 prolonged the QT interval and provoked ventricular tachyarrhythmias in 3 patients, mimicking long QT syndrome type 3.
Authors
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Alerts clinicians to proarrhythmic risk with DPI 201-106; leaves open generalizability and need for controlled evaluation.
Case Report (n=3)
Does acute administration of DPI 201-106 provoke long QT syndrome and ventricular tachyarrhythmias?
Delaying sodium channel inactivation with DPI 201-106 causes an acquired form of long QT syndrome mimicking LQT3, leading to dangerous ventricular arrhythmias.
Kühlkamp et al. (2003) conducted a case report in Acquired long QT syndrome (n=3). DPI 201-106 was evaluated on QT interval prolongation and ventricular tachyarrhythmias. Acute administration of DPI 201-106 prolonged the QT interval and provoked ventricular tachyarrhythmias in 3 patients, mimicking long QT syndrome type 3.