Drivers of Inflammation; Clonal Hematopoiesis: Clinical Implications

In recent years, growing evidence linking clonal hematopoiesis (CH) to aging, inflammation, inflammation-driven systemic diseases, cardiovascular risk, and cancer has increased interest in its role in disease evolution and somatic variation.In parallel, advances in next-generation and single-cell sequencing technologies, combined with computational modeling, have significantly improved our understanding of CH biology. 123 CH was initially identified through age-related skewing of X-chromosome inactivation and later associated with somatic TET2 mutations.It is now recognized as a fundamental age-related process characterized by the expansion of hematopoietic stem and progenitor cells carrying somatic variants and mosaic chromosomal alterations (mCAs), with prevalence increasing sharply with age.