In a phantom renal artery model, the Symplicity system formed larger lesions (mean depth 3.82 vs 3.44 mm, p<0.001) with lower catheter-tip temperatures compared to the EnligHTN system.
Does the Symplicity system produce different lesion sizes and thermodynamic characteristics compared to the EnligHTN system in a phantom renal artery model?
In a phantom renal artery model, the Symplicity renal denervation system formed larger lesions with lower catheter-tip temperatures compared to the EnligHTN system.
Absolute Event Rate: 3.82% vs 3.44%
p-value: p=<0.001
AIMS: Radiofrequency renal artery denervation has been used effectively to treat resistant hypertension. However, comparison of lesion and thermodynamic characteristics for different systems has not been previously described. We aimed to assess spatiotemporal lesion growth and ablation characteristics of Symplicity and EnligHTN systems. METHODS AND RESULTS: A total of 39 ablations were performed in a phantom renal artery model using Symplicity (n=17) and EnligHTN (n=22) systems. The phantom model consisted of a hollowed gel block surrounding a thermochromic liquid crystal (TLC) film, exhibiting temperature sensitivity of 50-78°C. Flow was simulated using 37°C normal saline with impedance equal to blood. Radiofrequency ablations with each system were delivered with direct electrode tip contact to the TLC. Lesion size was interpreted from the TLC as the maximum dimensions of the 51°C isotherm. Mean lesion depth was 3.82 mm±0.04 versus 3.44 mm±0.03 (p<0.001) for Symplicity and EnligHTN, respectively. Mean width was 7.17 mm±0.08 versus 6.23 mm±0.07 (p<0.001), respectively. With EnligHTN, steady state temperature was achieved 20 sec earlier, and was 15°C higher than Symplicity. CONCLUSIONS: In this phantom model, Symplicity formed larger lesions compared to EnligHTN with lower catheter-tip temperature. The clinical significance of our findings needs to be explored further.
Raisi et al. (Sun,) conducted a other in Phantom renal artery model (n=39). Symplicity renal denervation system vs. EnligHTN renal denervation system was evaluated on Mean lesion depth (p=<0.001). In a phantom renal artery model, the Symplicity system formed larger lesions (mean depth 3.82 vs 3.44 mm, p<0.001) with lower catheter-tip temperatures compared to the EnligHTN system.