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We show that a vesicle under shear flow experiences a lift force of hydrodynamical origin. This force is of purely viscous nature, and it originates from upstream-downstream asymmetry. At a critical shear rate 100--500Hz the vesicle, initially making adhesion with a substrate, undergoes an unbinding transition in two nontrivial steps. In the first step the lift force behaves as ^2, whereas in the second step as. We present numerical and analytical results on this phenomenon. We discuss several implications.
Cantat et al. (Mon,) studied this question.