Primary PTCA treatment delay of <3 hours significantly improved regional functional recovery of infarcted myocardium at 4 months compared to delays >3 hours (+21% vs +8% and +6%, P<0.02).
Observational (n=40)
Does the time to primary PTCA treatment influence regional functional recovery of infarcted myocardium in patients with first AMI?
Early reperfusion (<3 hours) by primary PTCA significantly improves regional functional recovery of infarcted myocardium at 4 months as assessed by CMR.
p-value: p=<0.02
PURPOSE: To assess with cardiac magnetic resonance imaging (CMR) the relationship between treatment delay and improvement of regional left ventricular function after primary percutaneous transluminal coronary angioplasty (p-PTCA) for acute myocardial infarction (AMI). MATERIALS AND METHODS: We performed cine- and late-enhancement (LE) CMR in 40 patients with first AMI after restoring TIMI 3 flow with p-PTCA and at a follow-up 4 months later. Infarcted segments were determined from LE images. Regional left ventricular function was quantified from cine-CMR images. Segmentation followed the American Heart Association 17-segments model. Patients were divided into groups with delay 12 hours. RESULTS: Segmental wall thickening (SWT) significantly iproved only in segments reperfused within 6 hours (P 3 hours (<3 hours: +21 +/- 3%, 3-6 hours: +8 +/- 4%, 6-12 hours: +6 +/- 3%; <3 hours to 3-6 hours, and 6-12 h, P < 0.02). CONCLUSION: We quantitatively demonstrated that time to p-PTCA treatment significantly influences regional functional recovery of infarcted myocardium at a 4-month follow-up.
Klug et al. (Thu,) conducted a observational in Acute myocardial infarction (n=40). Primary PTCA delay <3 hours vs. Primary PTCA delay >3 hours (3-6 hours, 6-12 hours, >12 hours) was evaluated on Improvement of regional left ventricular function (segmental wall thickening) (p=<0.02). Primary PTCA treatment delay of <3 hours significantly improved regional functional recovery of infarcted myocardium at 4 months compared to delays >3 hours (+21% vs +8% and +6%, P<0.02).