Why the study?
Current chronic heart failure models mostly use C57BL/6 mice and do not show clinically relevant characteristics of pulmonary congestion.
Does enalapril or furosemide improve pulmonary congestion, cardiac function, and survival in a BALB/c mouse model of post-MI heart failure?
Population
BALB/c mice after induction of myocardial infarction by permanent ligation of the left coronary artery
Comparison
Enalapril or furosemide vs vehicle or sham controls
Design
Preclinical animal model study
Key result
In a BALB/c mouse model of post-MI heart failure, enalapril reduced lung weight and pleural effusion and improved survival, while furosemide completely abolished pleural effusion.
Authors
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Enalapril effects in post-MI mouse HF merit translational trials; leaves open any change to clinical practice.
Does enalapril or furosemide improve pulmonary congestion, cardiac function, and survival in a BALB/c mouse model of post-MI heart failure?
The BALB/c mouse post-MI model successfully replicates clinically relevant pulmonary congestion and pleural effusion, providing a robust platform for testing novel heart failure therapies.
Ma et al. (2019) studied Heart failure. Enalapril or furosemide vs. Vehicle and sham controls was evaluated on Cardiac function, pulmonary congestion, disease biomarkers, and survival. In a BALB/c mouse model of post-MI heart failure, enalapril reduced lung weight and pleural effusion and improved survival, while furosemide completely abolished pleural effusion.