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Introduction Response inhibition, which stops an ongoing action, is important for daily life activities. Reportedly, noradrenaline (NA), a neurotransmitter, is involved in response inhibition. In recent years, transcutaneous auricular vagus nerve stimulation (taVNS) has gained attention for its ability to induce NA release in various areas of the brain. Thus, taVNS can potentially improve response inhibition; however, this remains unverified. Methods The present study investigated the effects of taVNS on response inhibition by measuring salivary alpha-amylase (sAA), an indirect indicator of NA. This study implemented a repeated-measures pre–post approach across conditions, with 24 healthy men (age, 21.3 ± 1.6 years) performing a stop signal task and undergoing sAA measurement before and after the taVNS intervention. taVNS was performed for 30 min at an intensity midway between the sensory and pain thresholds. Participants underwent two stimulation conditions, namely taVNS targeting the left concha and sham stimulation targeting the left earlobe, in a randomized order. Response inhibition was evaluated by comparing the stop signal reaction time (SSRT) before and after taVNS intervention. Results Under taVNS, sAA levels significantly increased after the stimulation. However, no significant difference in SSRT was observed between before and after the intervention under either condition. Discussion These results suggest that taVNS increases sAA levels after stimulation; however, it does not influence response inhibition, suggesting that the modulation of NA by taVNS is insufficient to improve response inhibition.
Yamamoto et al. (Thu,) studied this question.