Persistent hyperglycemia at 24 hours after symptom onset in patients with recanalized anterior AMI was independently associated with predischarge left ventricular dysfunction (OR 7.38, p=0.001).
Observational (n=210)
Does persistent hyperglycemia at 24 hours after symptom onset predict left ventricular dysfunction before discharge in patients with recanalized anterior acute myocardial infarction?
Persistent hyperglycemia 24 hours after symptom onset is a strong independent predictor of left ventricular dysfunction in patients with recanalized anterior acute myocardial infarction.
Effect estimate: OR 7.38
p-value: p=0.001
BACKGROUND: The relationship of changes in blood glucose concentrations after admission to left ventricular (LV) dysfunction in patients with recanalized anterior acute myocardial infarction (AMI) remains unclear. METHODS AND RESULTS: Blood glucose concentrations were measured on admission and 24 h after symptom onset in 210 patients with recanalized anterior AMI within 6 h of symptom onset. Of them, 142 had hyperglycemia on admission, defined as a blood glucose >or=8.9 mmol/L, and 68 patients did not. Among the patients with admission hyperglycemia, 49 had persistent hyperglycemia, defined as a blood glucose >or=8.9 mmol/L 24 h after onset, and 93 did not. The incidences of myocardial blush grade of 0/1 after recanalization indicating impaired myocardial perfusion (71%), and peak creatine kinase concentration (5,631+/-2,855 mU/ml) were higher and predischarge LV function (43+/-11%) was lower in patients with persistent hyperglycemia than in those without (p<0.01). Multivariate analysis showed that persistent hyperglycemia was independently associated with LV dysfunction, defined as a predischarge LV ejection fraction <or=40% (odds ratio 7.38, p=0.001). CONCLUSIONS: Persistent hyperglycemia at 24 h after symptom onset is associated with LV dysfunction before discharge in patients with recanalized anterior AMI.
Kosuge et al. (Mon,) conducted a observational in Recanalized anterior acute myocardial infarction (n=210). Persistent hyperglycemia vs. No persistent hyperglycemia was evaluated on Left ventricular dysfunction (predischarge LV ejection fraction <=40%) (OR 7.38, p=0.001). Persistent hyperglycemia at 24 hours after symptom onset in patients with recanalized anterior AMI was independently associated with predischarge left ventricular dysfunction (OR 7.38, p=0.001).