A recorded diagnosis of depression was associated with a significantly higher risk of ischaemic heart disease in men (adjusted OR 2.75; 95% CI 1.13 to 6.69; P=0.03), but not in women.
Case-Control (n=1,224)
No
Effect estimate: Adjusted OR 2.75 (95% CI 1.13 to 6.69)
p-value: p=0.03
Objective: To determine the relation between depression, anxiety, and use of antidepressants and the onset of ischaemic heart disease.Design: Population based case-control study.Setting: All 5623 patients registered with one general practice.Subjects: 188 male cases with ischaemic heart disease matched by age to 485 male controls without ischaemic heart disease; 139 female cases with ischaemic heart disease matched by age to 412 female controls.Main outcome measure: Adjusted odds ratios calculated by conditional logistic regression.Results: The risk of ischaemic heart disease was three times higher among men with a recorded diagnosis of depression than among controls of the same age (odds ratio 3.09; 95% confidence interval 1.33 to 7.21; P = 0.009).This association persisted when smoking status, diabetes, hypertension, and underprivileged area (UPA(8)) score were included in a multivariate model (adjusted 2.75; 1.13 to 6.69; P = 0.03).Men with depression within the preceding 10 years were three times more likely to develop ischaemic heart disease than were the controls (3.13; 1.27 to 7.70; P = 0.01).Men with ischaemic heart disease had a higher risk of subsequent ischaemic heart disease than men without ischaemic heart disease (adjusted 2.34; 1.34 to 4.10; P = 0.003).Depression was not a risk factor for ischaemic heart disease in women on multivariate analysis (adjusted 1.34; 0.70 to 2.56; P = 0.38).Anxiety and subsequent ischaemic heart disease were not significantly associated in men or women.Conclusion: Depression may be an independent risk factor for ischaemic heart disease in men, but not in women.
A Sat, study conducted a case-control in ischaemic heart disease (n=1,224). Depression vs. No depression was evaluated on Onset of ischaemic heart disease (Adjusted OR 2.75, 95% CI 1.13 to 6.69, p=0.03). A recorded diagnosis of depression was associated with a significantly higher risk of ischaemic heart disease in men (adjusted OR 2.75; 95% CI 1.13 to 6.69; P=0.03), but not in women.