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Summary1. Streptokinase transforms a proactivator in blood to an activator, which converts plasminogen to plasmin. Streptokinase does not react directly with plasminogen. 2. A low content of plasminogen pro-activator in bovine blood is the reason for the incomplete activation of preparations of bovine plasminogen by streptokinase. In human globulin a large excess of plasminogen activator is formed by streptokinase. 3. The large activities usually observed by the activation of human globulin with streptokinase is caused by the action of this activator on the plasminogen contained in the fibrin substrate.
Müllertz et al. (Sun,) studied this question.