A combined approach of radiofrequency ablation followed by cryoablation significantly increased freedom from atrial fibrillation (80%) compared with RFA alone (52%) or cryoablation alone (56%, P<0.05).
Cohort (n=75)
Does a combined approach of radiofrequency ablation followed by cryoablation reduce the rate of atrial fibrillation recurrence compared with either approach alone in patients with paroxysmal atrial fibrillation?
A combined approach of radiofrequency ablation followed by cryoablation significantly improved single-procedure freedom from atrial fibrillation compared to either technique alone in patients with paroxysmal AF.
Absolute Event Rate: 80% vs 52%
p-value: p=< 0.05
INTRODUCTION: Pulmonary vein (PV) isolation for atrial fibrillation (AF) often requires repeat procedures due to PV reconnection. We hypothesized that wide area cicumferential ablation using radiofrequency energy (RFA) followed by ostial PV ablation with a cryoablation balloon would reduce the rate of AF recurrence compared with either approach alone. METHODS AND RESULTS: A retrospective study compared outcomes in the first 25 consecutive patients undergoing PV isolation for paroxysmal AF using the combined approach, to consecutive controls using either approach alone. Demographic and procedural data were collected from a prospective database. Kaplan-Meier curves were used to analyse AF free survival and curves were compared using the log-rank test. Twenty-five patients were included in each group. There were no major complications. Minor complications included two transient phrenic nerve palsies and a haematoma in both the combined groups and the cryoablation alone groups. In the RFA group the only complication was a grounding plate burn. Follow-up was 2.2 years in the RFA group, 1.0 years in the cryoablation group, and 1.4 years in the combined group. All recurrences but one occurred within one year. Freedom from AF was significantly greater in the combined group (80%) compared with the RFA alone group (52%) and the cryoablation alone group (56%, both P < 0.05). CONCLUSION: The combined approach was safe and increased single procedure efficacy of PV isolation for AF compared with either technique alone.
Tayebjee et al. (Fri,) conducted a cohort in paroxysmal atrial fibrillation (n=75). Radiofrequency ablation followed by cryoablation vs. Radiofrequency ablation alone or cryoablation alone was evaluated on Freedom from atrial fibrillation (p=< 0.05). A combined approach of radiofrequency ablation followed by cryoablation significantly increased freedom from atrial fibrillation (80%) compared with RFA alone (52%) or cryoablation alone (56%, P<0.05).