Female sex was associated with a lower prevalence of major ECG abnormalities compared to male sex (4.6% vs 6.6%), though this difference was attenuated in ethnic minority groups.
Cross-Sectional (n=19,458)
Do sex differences in the prevalence of major ECG abnormalities vary across ethnic groups in adults without cardiovascular disease?
The lower prevalence of major ECG abnormalities typically seen in women compared to men is less apparent in ethnic minority groups, particularly among South-Asian Surinamese individuals, independent of conventional cardiovascular risk factors.
Absolute Event Rate: 4.6% vs 6.6%
OBJECTIVES: Major ECG abnormalities have been associated with increased risk of cardiovascular disease (CVD) burden in asymptomatic populations. However, sex differences in occurrence of major ECG abnormalities have been poorly studied, particularly across ethnic groups. The objectives were to investigate (1) sex differences in the prevalence of major and, as a secondary outcome, minor ECG abnormalities, (2) whether patterns of sex differences varied across ethnic groups, by age and (3) to what extent conventional cardiovascular risk factors contributed to observed sex differences. DESIGN: Cross-sectional analysis of population-based study. SETTING: Multi-ethnic, population-based Healthy Life in an Urban Setting cohort, Amsterdam, the Netherlands. PARTICIPANTS: 8089 men and 11 369 women of Dutch, South-Asian Surinamese, African Surinamese, Ghanaian, Turkish and Moroccan origin aged 18-70 years without CVD. OUTCOME MEASURES: Age-adjusted and multivariable logistic regression analyses were performed to study sex differences in prevalence of major and, as secondary outcome, minor ECG abnormalities in the overall population, across ethnic groups and by age-groups (18-35, 36-50 and >50 years). RESULTS: Major and minor ECG abnormalities were less prevalent in women than men (4.6% vs 6.6% and 23.8% vs 39.8%, respectively). After adjustment for conventional risk factors, sex differences in major abnormalities were smaller in ethnic minority groups (OR ranged from 0.61 in Moroccans to 1.32 in South-Asian Surinamese) than in the Dutch (OR 0.49; 95% CI 0.36 to 0.65). Only in South-Asian Surinamese, women did not have a lower odds than men (OR 1.32; 95% CI 0.96 to 1.84). The pattern of smaller sex differences in ethnic minority groups was more pronounced in older than in younger age-groups. CONCLUSIONS: The prevalence of major ECG abnormalities was lower in women than men. However, sex differences were less apparent in ethnic minority groups. Conventional risk factors did not contribute substantially to observed sex differences.
Bolijn et al. (Tue,) conducted a cross-sectional in Without cardiovascular disease (n=19,458). Female sex vs. Male sex was evaluated on Prevalence of major ECG abnormalities. Female sex was associated with a lower prevalence of major ECG abnormalities compared to male sex (4.6% vs 6.6%), though this difference was attenuated in ethnic minority groups.
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