Diastolic dysfunction was an independent predictor of atrial fibrillation recurrence after catheter ablation and was associated with decreased left atrial voltage.
Cohort (n=83)
Does diastolic dysfunction predict altered atrial substrate and worse outcomes of catheter ablation in patients with paroxysmal atrial fibrillation?
Diastolic dysfunction is associated with altered atrial substrate (decreased LA voltage) and predicts a higher risk of recurrence following catheter ablation for paroxysmal atrial fibrillation.
BACKGROUND: The presence of diastolic dysfunction increases the risk of atrial fibrillation (AF), and might be associated with the left atrial (LA) substrate. The aim of the present study was to investigate the relationships between the diastolic dysfunction, atrial substrate and outcome of the catheter ablation. METHODS AND RESULTS: Eighty-three patients with paroxysmal AF were enrolled. Diastolic dysfunction was defined as a left ventricular ejection fraction (LVEF) of ≥ 50%, and one of the following criteria: (1) a mitral inflow early filling velocity to atrial filling velocity ratio (E/A) of ≤ 0.75; or (2) an E/A ratio of >0.75 and a ratio of the mitral inflow early filling velocity to the velocity of the early medial mitral annular ascent of >10. Patients with diastolic dysfunction were older than those with normal cardiac function. There were no differences in the other baseline characteristics, LA diameter, or LVEF. A decreased LA voltage, and higher recurrence rate were noted in patients with diastolic dysfunction. In the univariate analysis, the patients with recurrence had a lower LA voltage and greater diastolic dysfunction. The multivariate analysis also indicated diastolic dysfunction and LA voltage as independent predictors of recurrence. CONCLUSIONS: The patients with diastolic dysfunction developed a different atrial substrate and had a worse outcome of catheter ablation for atrial fibrillation.
Hu et al. (Fri,) conducted a cohort in Paroxysmal Atrial Fibrillation (n=83). Diastolic dysfunction vs. Normal diastolic function was evaluated on Recurrence of atrial fibrillation. Diastolic dysfunction was an independent predictor of atrial fibrillation recurrence after catheter ablation and was associated with decreased left atrial voltage.