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April 22, 2009The Journal of Physiological SciencesOpen Access

In a computational model of heart failure, a pulsatile left ventricular assist device in counter-pulsation mode provided the highest coronary perfusion and lowest peak left ventricular pressure.

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Why the study?

Does a pulsatile LVAD with counter-pulsation mode improve coronary perfusion and reduce ventricular afterload compared to co-pulsation or continuous flow modes in a computational heart failure model?

Population

A 16-compartment computational cardiovascular system model simulating heart failure.

Comparison

Pulsatile left ventricular assist device… vs Pulsatile LVAD operating in co-pulsation mode…

Design

Preclinical

Key result

In a computational model of heart failure, a pulsatile left ventricular assist device in counter-pulsation mode provided the highest coronary perfusion and lowest peak left ventricular pressure.

Authors

KLKi Moo LimIKIn Su KimSCSeong Wook Choi

Discussion

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Overview

Cautious interpretation required for this computational model; leaves open whether counter-pulsation LVAD modes improve outcomes in clinical heart failure.

Structured PICO

Does a pulsatile LVAD with counter-pulsation mode improve coronary perfusion and reduce ventricular afterload compared to co-pulsation or continuous flow modes in a computational heart failure model?

P
Population
A 16-compartment computational cardiovascular system model simulating heart failure (implemented by decreasing end-systolic elastance to 40% of normal and blocking the control path of cardiac contractility).
I
Intervention
Pulsatile left ventricular assist device (LVAD) operating in counter-pulsation mode (mean flow rate 5,000 ml/min).
C
Comparator
Pulsatile LVAD operating in co-pulsation mode and LVAD operating in continuous flow mode (mean flow rate 5,000 ml/min).
O
Outcome
Coronary blood perfusion and peak pressure of the left ventricle (ventricular afterload).surrogate

Main Result

Absolute Event Rate: 43% vs 51%

In a computational model of heart failure, a pulsatile LVAD operating in counter-pulsation mode provided superior coronary perfusion and greater reduction in ventricular afterload compared to continuous flow or co-pulsation modes.

Limitations

  • Omitted right coronary flow for simplification
  • Results are based on a computational simulation rather than in vivo or clinical data

Cite This Study

Lim et al. (2009) studied Heart failure (computational model). Pulsatile LVAD in counter-pulsation mode vs. Co-pulsation and continuous flow modes was evaluated on Peak left ventricular pressure (mmHg). In a computational model of heart failure, a pulsatile left ventricular assist device in counter-pulsation mode provided the highest coronary perfusion and lowest peak left ventricular pressure.

synapsesocial.com/papers/6a17b51abee663e365ac7b5chttps://doi.org/10.1007/s12576-009-0037-7
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