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When a PLC-γ1–based light switch tells a cell which way to go | Synapse

May 28, 2026

When a PLC-γ1–based light switch tells a cell which way to go

Key Points

The aim is to explore how light-activated PLC-γ1 influences cell movement and polarity.
Engineered a light-sensitive version of PLC-γ1.
Activated PLC-γ1 in specific regions of the cell membrane.
Assessed the impact on directional migration of cells.
Activation of light-controlled PLC-γ1 in illuminated regions enhanced cell migration.
Findings redefine PLC-γ1 as a key signal in controlling cell polarity.

Abstract

Appalabhotla et al. (https://doi.org/10.1083/jcb.202507177) engineer a light-controlled version of PLC-γ1 (PLC-γ1) and show that activating it in an illuminated region of the cell membrane drives directional migration. The work redefines PLC-γ1 as an instructive signal in control of cell polarity.

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Cite This Study

Sun et al. (Wed,) studied this question.

synapsesocial.com/papers/6a17dd4e3fad632b0f9da0cd https://doi.org/https://doi.org/10.1083/jcb.202605005