Clinical Epidemiology

Special Article1 December 1968Clinical EpidemiologyIII. The Clinical Design of Statistics in TherapyALVAN R. FEINSTEIN, M.D., F.A.C.P.ALVAN R. FEINSTEIN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-69-6-1287 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOUTLINE OF CONTENTS: PART IIIINTRODUCTIONPROGNOSTIC DISTINCTIONSINDEX OF ACCOMPLISHMENTCORRELATED PROGNOSTIC STRATIFICATIONTHE ASSESSMENT OF CO-MORBIDITYPOPULATIONAL TRANSFERSINVESTIGATOR'S CHOICE OF TEMPORAL DEMARCATIONSDECISIONS MADE BY PATIENTS AND DOCTORSTAXONOMIC LOGISTICSNONCLINICAL PRINCIPLES"CONTROL" TREATMENTDOUBLE-BLIND TECHNIQUERANDOM ALLOCATIONSUMMARYINTRODUCTIONPerhaps the most striking intellectual change in modern treatment has been its frequent conversion from an act of clinical medicine to an act of statistics.Reports that lack appropriate statistical analysis will regularly be rejected today by the editors of leading medical journals; various papers in contemporary medical literature recurrently provide instructive discussions of statistical principles useful...References1. FEINSTEIN AR: Clinical epidemiology. I. The populational experiments of nature and of man in human illness. Ann. Intern. Med. 69: 807, 1968. LinkGoogle Scholar2. LOUIS PC: An Essay on Clinical Instruction, translated by MARTIN, P., S. Highley, London, 1834. Google Scholar3. GREENWOOD M: Louis and the numerical method, in The Medical Dictator and Other Biographical Studies, Williams and Norgate, Ltd., London, 1936, pp. 123-142. Google Scholar4. UNDERWOOD EA: The history of the quantitative approach in medicine. Brit. Med. Bull. 7: 265, 1951. CrossrefMedlineGoogle Scholar5. LOUIS PC: Researches on the Effects of Bloodletting in Some Inflammatory Diseases and on the Influence of Tartarized Antimony and Vesication in Pneumonitis, translated by PUTNAM, C. G., Hilliard, Gray and the Departments of Medicine and Epidemiology, Yale University School of Medicine, New Haven; Conn.This study was supported in part by grant 13977-03-68-06, Department of Health, Education, and Welfare, U. S. Public Health Service Cancer Control Program, Washington, D. C.Requests for reprints should be addressed to Alvan R. Feinstein, M.D., Yale University School of Medicine, 333 Cedar St., New Haven, Conn. 06510 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCOVID-19 and the future of clinical epidemiologyEvidence‐based medicine's curious path: From clinical epidemiology to patient‐centered care through decision analysisTwenty Years of the Cochrane Tobacco Addiction Group: Past, Present, and FutureMultimorbilidad auto-reportada por el adulto mayor del departamento de Antioquia: prevalencia y factores asociadosCan the quality and clinical relevance of Equine Veterinary Journal publications be improved? A time for reflection and refinementMultimorbilidad: bases conceptuales, modelos epidemiológicos y retos de su mediciónThe incident user design in comparative effectiveness researchClinical epidemiologyPreventing problems in prevention researchThe Teaching of Statistics in the Biological, Medical and Health Sciences: Some Comments and a Selected BibliographyDIAGNOSTIC ERRORS AND THEIR IMPACT ON DISEASE TRENDSEpidemiologic Approach to CancerThe importance of classifying initial co-morbidity in evaluating the outcome of diabetes mellitusReview of Pattern Recognition in Medical Diagnosis and Consulting Relative to a New System ModelMedical Intensive Care in the Teaching Hospital: Costs Versus Benefits The Need for an AssessmentPAUL F. GRINER, M.D., F.A.C.P.The Clinical Course in Muscular Subaortic Stenosis A Retrospective and Prospective Study of 60 Hemodynamically Proved CasesA. G. ADELMAN, M.D., E. D. WIGLE, M.D., F.A.C.P., N. RANGANATHAN, M.B.B.S., G. D. WEBB, M.D., B. S. L. KIDD, M.D., W. G. BIGELOW, M.D., M. D. SILVER, M.B.B.S., Ph.D.The pre-therapeutic classification of co-morbidity in chronic diseaseWhat Kind of Basic Science for Clinical Medicine?A Short History of Evidence-Based MedicineA Critique of Methodology in Studies of Anticoagulant Therapy for Acute Myocardial Infarction 1 December 1968Volume 69, Issue 6Page: 1287-1312KeywordsCancer treatmentClinical decision support systemsClinical epidemiologyHealth statisticsHospital medicineMedical servicesPopulation statistics Issue Published: 1 December 1968 PDF DownloadLoading ...